CB-5083

p97/VCP ATPase inhibitor (PDE6 off-target)

Ph. I in cancer (discont., dyschromatopsia)

from HTS of NIH compound library

J. Pharmacol. Exp. Ther., Apr. 30, 2021

Cleave Therapeutics, San Francisco, CA

The Cleave Therapeutics p97 (VCP) inhibitor, CB-5083, was a Ph. I clinical candidate for cancer that was terminated due to vision side effects including causing patients to see unusual colors…


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