KRAS(G12C)ON-cyclophilin A tri-complex inh.

overcomes KRAS resist. mut. in PDX model

natural product related (sanglifehrin); undiscl.

Cancer Discov., Apr. 6, 2021

Revolution Medicines, Redwood City, CA

RM-018

The Revolution Medicines KRASG12C inhibitor, RM-018, “glues” KRASG12C to the highly abundant chaperone protein, cyclophilin A, in a tri-complex (KRAS- inhibitor-cyclophilin A) stabilized by protein-protein interactions. KRAS is a driver of cancer cell growth,…


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