ABHD17 serine hydrolase covalent inhibitor
reduction of N-Ras signaling, AML cell growth
5k cmpd ser. hydrolase directed screen + opt.
Nature Chem. Biol., Apr. 29, 2021
Scripps (TSRI) / UCSF / Lundbeck
The TSRI/UCSF/Lundbeck pan-ABHD17 serine hydrolase covalent inhibitor, ABD957, impairs N-Ras depalmitoylation in AML cells, reducing N-Ras signaling and growth of NRAS-mutant AML cells. This pyrazole urea is significantly more selective…