ABHD17 serine hydrolase covalent inhibitor

reduction of N-Ras signaling, AML cell growth

5k cmpd ser. hydrolase directed screen + opt.

Nature Chem. Biol., Apr. 29, 2021

Scripps (TSRI) / UCSF / Lundbeck

The TSRI/UCSF/Lundbeck pan-ABHD17 serine hydrolase covalent inhibitor, ABD957, impairs N-Ras depalmitoylation in AML cells, reducing N-Ras signaling and growth of NRAS-mutant AML cells. This pyrazole urea is significantly more selective…

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