FXR nucl. receptor + TGR5 GPCR dual agonist

dual in vivo effects at 100 mpk PO

from merger of literature agonist fragments

Sci. Rep., Apr. 28, 2021

Fuji Yakuhin Co., Ltd., Saitama, JP

compound-20p

The Fuji Yakuhin FXR/TGR5 non-bile acid dual agonist, compound 20p, simultaneously activates the FXR nuclear receptor and the unrelated TGR5 GPCR receptor when dosed orally in vivo. FXR has been…


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