Chemical structure of molecule NVS-BET-1

BRD4 (BD1/2) BET bromodomain inhibitor

wound-heal. at 1 mpk QD, bell-shaped pharm.

from phenotypic screen (MDM2 inhibitor hit)

Nat. Chem. Biol., Jan. 18, 2021

Novartis (NIBR), Basel, CH

The Novartis BET bromodomain inhibitor, NVS-BET-1, is a new chemotype of BRD4 (BD1 and BD2) inhibitor. While we recently highlighted a few high-profile, selective bromodomain inhibitors from AbbVie and…

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