© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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oral, brain-penetrant O-GlcNAcase (OGA) inh.
structurally distinct in vivo tool
from virtual screen of 100k cmpd, testing 2681
J. Med. Chem., Jan. 6, 2021
Takeda Pharmaceutical, Fujisawa, JP
The Takeda O-GlcNAcase (OGA) inhibitor, “compound 5i,” binds to the same site as prior sugar-based OGA inhibitors, but has surprisingly different chemical properties and a unique binding mode. The…
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