covalent inh. of remote ALK kinase cysteine

thought-provoking proposed MoA

from ceritinib and linker opt.

J. Med. Chem., Jan. 20, 2021

Sichuan University / Tsinghua University, CN

Chemical structure of molecule Con B-1 ALKi inhibitor

The academic covalent ALKi inhibitor, Con B-1, is thought-provoking initial proof-of-concept that remote kinase cysteines might be targetable from an active-site inhibitor. The authors show that a derivative of…


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