Chemical structure of molecule Dosimertinib inhibitor

deuterated covalent mut. EGFR inhibitor

wider TI in model, Ph. I in China

deuteration reduces less sel. matabolite

J. Med. Chem., Jan. 18, 2021

ZZU / HNU / Henan Genuine Biotech Co., CN

The Henan EGFR inhibitor, dosimertinib, is a deuterated derivative of the approved covalent inhibitor, osimertinib. A metabolite of osimertinib, AZ5104, has lower selectivity for WT EGFR than mutant EGFR,…

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