Chemical structure of molecule E7386 modulator

oral, selective beta-catenin/CBP PPI inhibitor

synergy w/ PD-1i in model, in Ph. I for cancer

opt. of prior peptidomimetic candidate

Cancer Res., Jan. 6, 2021

Eisai Co., Ltd., Tsukuba, JP

The Eisai β-catenin/CBP inhibitor, E7386, is an orally active and selective inhibitor of the β-catenin/CBP protein-protein interaction, a key node in the long studied Wnt/β-catenin pathway in cancer. Prior…

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