p300/CBP bromodomain inhibitor

PD observed in serial biopsies from Ph. I

50 mg QD, 3-d-on-4-off; origin not discussed

Cancer Discovery, Jan. 11, 2021

ICR / Royal Marsden / CellCentric, UK

The CellCentric p300/CBP inhibitor, CCS1477, is an orally available drug in early development for advanced prostate cancer, and is structurally distinct from the p300/CBP inhibitor we covered in Apr.…


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