molecules of the month

“compound 16”

nanomolar HIV-1 maturation inhibitor

interesting structure

derivative of GSK3532795/BMS955176

Bioorg. Med. Chem. Lett., Jan. 26, 2021

Bristol Myers Squibb, CT + NJ

Chemical structure of compound 16 BMS HIV-1 maturation inhibitor
1 min read

The BMS HIV-1 maturation inhibitor, “compound 16,” is a potent derivative of the clinical candidate GSK3532795/955176, with double-digit nanomolar activity in cells. The spiro[3.3]hept-5-ene effectively replaces a phenyl ring its parent molecule. Though it wasn’t taken beyond an in vitro assay, the structure is worth noting in the mental isostere toolbox.

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