oral PAR4 antagonist
Ph. II completed in thrombosis (discontinued)
HTS, potency, and PK opt.
J. Med. Chem.
Bristol-Myers Squibb, Princeton, NJ
Context. BMS-986120, (BMS) is an oral protease-activated receptor 4 (PAR4) inhibitor that was being developed for arterial thrombosis. PAR4 was long considered a redundant “backup” receptor to the more…