3 minute read
Jul. 27, 2022

Iclepertin: an Oral Glycine Transporter-1 (GlyT1) Inhibitor


oral GlyT1 inhibitor Ph. III candidate in schizophrenia 10 and 25 mg PO QD efficacy in CIAS improv. J. Pharmacol. Exp. Ther. Boehringer Ingelheim Pharma, Biberach an der Riss, DE

Drug Hunter Team

Context. Iclepertin (BI 425809; Boehringer Ingelheim) is an oral glycine transporter-1 (GlyT1) inhibitor being developed for cognitive impairment associated with schizophrenia (CIAS) . The ineffectiveness of currently available antipsychotic medications in improving negative symptoms and cognitive deficits leaves a significant unmet need for [...]



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