oral BRAF inhibitor, brain penetrant

effective in A375-derived mouse models

from prior paradox inducing BRAF inhibitors

Clinical Cancer Research

Roche

6.     The Roche BRAF inhibitor, compound Ia, is designed to address the limitations of existing BRAFi/MEKi inhibitor combinations. It is a RAF paradox breaker (see belvarafenib) and is brain penetrant, offering…


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