oral BRAF inhibitor, brain penetrant

effective in A375-derived mouse models

from prior paradox inducing BRAF inhibitors

Clinical Cancer Research

Roche

Chemical structure of molecule compound Ia Roche BRAF inhibitor

6.     The Roche BRAF inhibitor, compound Ia, is designed to address the limitations of existing BRAFi/MEKi inhibitor combinations. It is a RAF paradox breaker (see belvarafenib) and is brain penetrant, offering…


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