oral BRAF inhibitor, brain penetrant
effective in A375-derived mouse models
from prior paradox inducing BRAF inhibitors
Clinical Cancer Research
Roche
“compound Ia”
6. The Roche BRAF inhibitor, compound Ia, is designed to address the limitations of existing BRAFi/MEKi inhibitor combinations. It is a RAF paradox breaker (see belvarafenib) and is brain penetrant, offering…