TRPM8 blocker for ocular administration

effective w/ ocular admin. in animal model

cell-based screen. and opt. of thiazoles series

Journal of Medicinal Chemistry

Dompé Farmaceutici S.p.A

Chemical structure of compound 59 Dompé Farmaceutici TRPM8 blocker

12. The Dompé Farmaceutici TRPM8 blocker, compound 59 is a potent (IC50 = 11 nM) compound for painful ocular conditions, with ocular efficacy in a preclinical behavioral model. TRPM8 is a cation…


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