TRPM8 blocker for ocular administration
effective w/ ocular admin. in animal model
cell-based screen. and opt. of thiazoles series
Journal of Medicinal Chemistry
Dompé Farmaceutici S.p.A
compound 59
12. The Dompé Farmaceutici TRPM8 blocker, compound 59 is a potent (IC50 = 11 nM) compound for painful ocular conditions, with ocular efficacy in a preclinical behavioral model. TRPM8 is a cation…