TRPM8 blocker for ocular administration

effective w/ ocular admin. in animal model

cell-based screen. and opt. of thiazoles series

Journal of Medicinal Chemistry

Dompé Farmaceutici S.p.A

12. The Dompé Farmaceutici TRPM8 blocker, compound 59 is a potent (IC50 = 11 nM) compound for painful ocular conditions, with ocular efficacy in a preclinical behavioral model. TRPM8 is a cation…


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