oral selective VPS34 kinase inhibitor

discontinued due to potential toxicity

SBDD and SAR optimization

Journal of Medicinal Chemistry

Genentech Inc.

Chemical structure of Genentech VPS34 kinase inhibitor, compound 5

11.   The Genentech VPS34 kinase inhibitor, compound 5, is a selective kinase inhibitor that is unusually polar for a kinase inhibitor (logD = 1.0, PPB = 23%) but maintains low clearance.…

get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: