oral CDK8 kinase inhibitor

effective in ovariectomized rat model

CDK8 identified as MoA after screen

Bioorganic & Medicinal Chemistry Letters

Daiichi Sankyo Co. Ltd.

Chemical structure of molecule DS96432529 Daiichi Sankyo CDK8 kinase inhibitor

7.     The Daiichi Sankyo CDK8 kinase inhibitor, DS96432529, is intended to be a bone anabolic agent. The molecule shows preclinical efficacy and synergy with alendronate or parathyroid hormone. The discovery…

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