potent, selective, oral gamma-secretase modulator

PD effect on A-beta in model, well-tol. in 2 species

from optimization of prior ligand

ACS Med. Chem. Lett., May 1, 2020

Roche, Basel, CH

RO7185876 is a gamma-secretase modulator (GSM) intended for treatment of Alzheimer’s disease. GSMs, which act by stabilizing the enzyme/substrate complex to promote generation of shorter peptides rather than inhibiting enzyme…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: