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Sep. 18, 2021

RO7185876: A gamma-secretase modulator


potent, selective, oral gamma-secretase modulator PD effect on A-beta in model, well-tol. in 2 species from optimization of prior ligand ACS Med. Chem. Lett., May 1, 2020 Roche, Basel, CH

Drug Hunter Team

RO7185876 is a gamma-secretase modulator (GSM) intended for treatment of Alzheimer’s disease. GSMs, which act by stabilizing the enzyme/substrate complex to promote generation of shorter peptides rather than inhibiting enzyme activity, and hence are anticipated to be less toxic than gamma-secretase inhibitors (GSI’s) which were abandoned due [...]



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