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RO7185876 is a gamma-secretase modulator (GSM) intended for treatment of Alzheimer’s disease. GSMs, which act by stabilizing the enzyme/substrate complex to promote generation of shorter peptides rather than inhibiting enzyme activity, and hence are anticipated to be less toxic than gamma-secretase inhibitors (GSI’s) which were abandoned due to serious safety liabilities. This compound competed two-week toxicology studies in two species (including one non-rodent), supporting its potential advancement to GLP tox. studies.