fbpx

molecules of the month

RMC-6291

oral KRASG12C(ON) tri-complex inhibitor

Ph. I/Ib for adv. solid tumors

from FBDD + SBDD

AACR, April 2023

Revolution Medicines, Redwood City, CA

RMC-6291,KRASG12C, oral KRASG12C(ON) tri-complex inhibitor, Ph. I/Ib for adv. solid tumors, from FBDD + SBDD, AACR, April 2023, REVOLUTION MEDICINES, REDWOOD CITY, CA
7 mins read

And now for something completely different. The recent approvals of Ras(off)-targeting KRASG12C inhibitors sotorasib and adagrasib, decades in the making, mark the beginning of a new phase of KRAS drug discovery. Clinical data with both molecules suggest that there are opportunities for brain-penetrant KRAS inhibitors, a need for novel modalities to address drug resistance and the spectrum of KRAS mutants beyond KRASG12C, and a need for better tolerated molecules that can combine well with other classes of therapies like immunotherapy. While an increasing number of follow-on KRAS inhibitors are emerging with similar mechanisms of action to sotorasib, Revolution Medicines’ RMC-6291 is representative of a completely novel approach that could become a strong addition to the clinical toolbox for KRAS, but…


request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.


already a member? log in: