potent oral autotaxin phosphodiesterase inh.

orally efficacious in xenograft

from HTS and ligand-based design

ACS Med. Chem. Lett., May 19, 2020

Ono Pharmaceutical, Osaka, JP

ONO-8430506 is a potent autotaxin phosphodiesterase inhibitor with significant oral exposure and low clearance in higher species. Autotaxin contributes to lysophosphatidic acid (LPA) production has been explored as a target…


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