© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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potent oral autotaxin phosphodiesterase inh.
orally efficacious in xenograft
from HTS and ligand-based design
ACS Med. Chem. Lett., May 19, 2020
Ono Pharmaceutical, Osaka, JP
ONO-8430506 is a potent autotaxin phosphodiesterase inhibitor with significant oral exposure and low clearance in higher species. Autotaxin contributes to lysophosphatidic acid (LPA) production has been explored as a target…
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