oral prodrug of IDO1 inhibitor

completed Ph. I in solid tumors

from derivatization of indoximod

Eur. J. Med. Chem., May 1, 2020

NewLink Genetics, Ames, IA

Structure of NLG802, a prodrug of indoximod

NLG802 is a prodrug of the IDO1 inhibitor indoximod with significantly enhanced oral exposure. Both the acid and amine functionalities of indoximod are protected as an ethyl ester and…

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