oral prodrug of IDO1 inhibitor
completed Ph. I in solid tumors
from derivatization of indoximod
Eur. J. Med. Chem., May 1, 2020
NewLink Genetics, Ames, IA
NLG802
NLG802 is a prodrug of the IDO1 inhibitor indoximod with significantly enhanced oral exposure. Both the acid and amine functionalities of indoximod are protected as an ethyl ester and…