potent, BP, NAPE-PLD zinc hydrolase inhibitor

brain penetrant IP tool compound

from HTS and optimization

Nat. Chem. Biol., May 11, 2020

Leiden University, Leiden, NL

LEI401 is a selective, brain-penetrant inhibitor of NAPE-PLD, an enzyme involved in the biosynthesis of various N-acylethanolamine (NAE) signaling lipids, and is a potentially useful tool molecule for understanding…

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