molecules of the month


potent, BP, NAPE-PLD zinc hydrolase inhibitor

brain penetrant IP tool compound

from HTS and optimization

Nat. Chem. Biol., May 11, 2020

Leiden University, Leiden, NL

1 min read

LEI401 is a selective, brain-penetrant inhibitor of NAPE-PLD, an enzyme involved in the biosynthesis of various N-acylethanolamine (NAE) signaling lipids, and is a potentially useful tool molecule for understanding the basic biology around this target. The compound emerged as the result of an academic collaboration, including an HTS done with the European Lead Factory. This looks to be a promising example of how academic institutions can collaboratively generate and validate useful tools for basic research.

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