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Sep. 18, 2021

LEI401: A selective and Brain-Penetrant Inhibitor of NAPE-PLD


potent, BP, NAPE-PLD zinc hydrolase inhibitor brain penetrant IP tool compound from HTS and optimization Nat. Chem. Biol., May 11, 2020 Leiden University, Leiden, NL

Drug Hunter Team

LEI401 is a selective, brain-penetrant inhibitor of NAPE-PLD, an enzyme involved in the biosynthesis of various N-acylethanolamine (NAE) signaling lipids, and is a potentially useful tool molecule for understanding the basic biology around this target. The compound emerged as the result of an academic collaboration, including an HTS done with [...]



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