A Chameleonic Allosteric Inhibitor of WRN Helicase for MSI-High and dMMR Tumors

HRO761

allosteric inhibitor of WRN helicase Ph. I/Ib for MSI-high solid tumors from HTS, SBDD, and LipE-guided opt. ACS Spring 2024 meeting; Nature, April 2024 Novartis Biomedical Research, Basel, CH

Authors:

Shaima Qunies,

Dennis C. Koester

Reviewers:

Lew Pennington,

Dennis X. Hu

Editor:

Rory McAtee

A Chameleonic Allosteric Inhibitor of WRN Helicase for MSI-High and dMMR Tumors

HRO761

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