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folate receptor-dependent PROTAC conjugate
FOLR1-dependent MEK1/2 degrad. in vitro
rom conjugation of folate to PROTAC
J. Am. Chem. Soc., May 10, 2021
Harvard Medical / Mt. Sinai
The FOLR1-targeting folate receptor-dependent PROTAC conjugate, folate-MS432, is a MEK1/2 degrader that is targeted to FOLR1, a receptor highly expressed in many cancer cell types but less so in most…
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