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epoxide-based covalent BTK inhibitor
cysteine reactive, Kinact/Ki ~ 6500
from covalent DEL library screening
Bioorg. & Med. Chem. Lett., May 19, 2021
X-Chem Inc., Waltham, MA
the X-Chem covalent BTK inhibitor, compound 6, is an example of a covalent inhibitor discovered using DNA-encoded library chemistry, and is the first epoxide-based covalent inhibitor discovered against BTK. Screening…
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