epoxide-based covalent BTK inhibitor

cysteine reactive, Kinact/Ki ~ 6500

from covalent DEL library screening

Bioorg. & Med. Chem. Lett., May 19, 2021

X-Chem Inc., Waltham, MA


the X-Chem covalent BTK inhibitor, compound 6, is an example of a covalent inhibitor discovered using DNA-encoded library chemistry, and is the first epoxide-based covalent inhibitor discovered against BTK. Screening…

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