fbpx

molecules of the month

JNJ-61803534

oral ROR_t inverse agonist

Ph. I in HV up to 200 mg w/ PD, discontinued

from HTS + opt.

Scientific Reports, May 26, 2021

Janssen R&D, La Jolla, CA

JNJ-61803534
2 mins read

The Janssen RORgt inhibitor, JNJ-61803534, is an oral clinical candidate that was well-tolerated in humans up to 200 mg and demonstrated PD. Unfortunately, development was terminated due to findings in a rabbit embryo-fetal study where fetal development was impacted by JNJ-61803534 treatment. The JNJ team shares a lot of useful human data in the paper, including human PK (half-life of 164-170 h!) and PD. The variability in the human PD data is a good reminder that clinical data is often a lot noisier than preclinical data. When drug toxicity is a potential concern, the variability in PK and PD in humans makes it more difficult to find an optimal dose in practice than it might sound on paper. JNJ-61803534 was well…


request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.


already a member? log in: