oral ROR_t inverse agonist

Ph. I in HV up to 200 mg w/ PD, discontinued

from HTS + opt.

Scientific Reports, May 26, 2021

Janssen R&D, La Jolla, CA

The Janssen RORgt inhibitor, JNJ-61803534, is an oral clinical candidate that was well-tolerated in humans up to 200 mg and demonstrated PD. Unfortunately, development was terminated due to findings in…

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