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Sep. 18, 2021

JNJ-61803534: An Oral RORγt Inverse Agonist

JNJ-61803534

oral ROR_t inverse agonist Ph. I in HV up to 200 mg w/ PD, discontinued from HTS + opt. Scientific Reports, May 26, 2021 Janssen R&D, La Jolla, CA

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Drug Hunter Team

The Janssen RORgt inhibitor, JNJ-61803534 , is an oral clinical candidate that was well-tolerated in humans up to 200 mg and demonstrated PD. Unfortunately, development was terminated due to findings in a rabbit embryo-fetal study where fetal development was impacted by JNJ-61803534 treatment. The JNJ team shares a lot of useful human data in [...]

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