first-in-class eIF4A RNA helicase inhibitor

in clinical dev. for solid tumors (Ph. I, IV QW)

from optimization of a natural product

J. Med. Chem., May 29, 2020

eFFECTOR Therapeutics, San Diego, CA

eFT226 (zotatifin) is a beautiful natural product-derived molecule that inhibits the RNA helicase eIF4A by forming a ternary complex between it, eIF4A, and polypurine RNA. Interestingly, the stability of the…

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