first-in-class eIF4A RNA helicase inhibitor
in clinical dev. for solid tumors (Ph. I, IV QW)
from optimization of a natural product
J. Med. Chem., May 29, 2020
eFFECTOR Therapeutics, San Diego, CA
eFT226 (zotatifin)
eFT226 (zotatifin) is a beautiful natural product-derived molecule that inhibits the RNA helicase eIF4A by forming a ternary complex between it, eIF4A, and polypurine RNA. Interestingly, the stability of the…