potent, selective NaV1.7 ion channel inhibitor

completed Ph. I in HV, discontinued in Ph. II

from optimization of known starting point

J. Med. Chem., May 26, 2020

Daiichi Sankyo, Tokyo, JP


DS-1971a is a potent, isoform-selective selective arylsulfonamide NaV1.7 inhibitor intended for the treatment of neuropathic pain. It has a surprisingly long residence time on NaV1.7, which the authors suggest contributes…

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