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Sep. 18, 2021

DS-1971a: A potent, Isoform-Selective Arylsulfonamide NaV1.7 Inhibitor


potent, selective NaV1.7 ion channel inhibitor completed Ph. I in HV, discontinued in Ph. II from optimization of known starting point J. Med. Chem., May 26, 2020 Daiichi Sankyo, Tokyo, JP

Drug Hunter Team

DS-1971a is a potent, isoform-selective selective arylsulfonamide NaV1.7 inhibitor intended for the treatment of neuropathic pain. It has a surprisingly long residence time on NaV1.7, which the authors suggest contributes to better than predicted in vivo activity. 1971a is a good example of a compound which was successfully advanced to [...]



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