molecules of the month

“Compound 6g”

potent, reversible MAGL serine hydrolase inh.

orally efficacious in inflamm. pain model

from optimization of prior ligand

Bioorg. Med. Chem. Lett., May 7, 2020

Janssen R&D, Spring House, PA

Structure of compound 6g
1 min read

“Compound 6g” is a potent, selective, and reversible inhibitor of monoacylglycerol lipase (MAGL), which degrades the cannabinoid receptor (CB) agonist 2-arachidononylglycerol (2-AG) to arachadonic acid (AA). Inhibition of MAGL therefore indirectly agonizes CB receptors and reduces inflammatory AA levels, which may be beneficial for a range of disorders. In contrast to most prior MAGL inhibitors which are covalent modifiers, this compound is a reversible inhibitor.

request a trial

Drug Hunter is commited to helping industry innovators make informed decisions. Premium members have access to our library of the latest stories in science, written by scientists.

Request a trial to access insights powering the pros in our industry.

already a member? log in: