potent, reversible MAGL serine hydrolase inh.

orally efficacious in inflamm. pain model

from optimization of prior ligand

Bioorg. Med. Chem. Lett., May 7, 2020

Janssen R&D, Spring House, PA

“Compound 6g” is a potent, selective, and reversible inhibitor of monoacylglycerol lipase (MAGL), which degrades the cannabinoid receptor (CB) agonist 2-arachidononylglycerol (2-AG) to arachadonic acid (AA). Inhibition of MAGL therefore…


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