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Sep. 18, 2021

Compound 6g: a Potent, Selective, and Reversible Inhibitor of Monoacylglycerol Lipase

“compound 6g”

potent, reversible MAGL serine hydrolase inh. orally efficacious in inflamm. pain model from optimization of prior ligand Bioorg. Med. Chem. Lett., May 7, 2020 Janssen R&D, Spring House, PA

Drug Hunter Team

“Compound 6g” is a potent, selective, and reversible inhibitor of monoacylglycerol lipase (MAGL), which degrades the cannabinoid receptor (CB) agonist 2-arachidononylglycerol (2-AG) to arachadonic acid (AA). Inhibition of MAGL therefore indirectly agonizes CB receptors and reduces inflammatory AA levels, which may be beneficial for a range of [...]



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