mech.-based inh. of monoamine oxidase LSD1

orally efficacious in xenograft model

from optimization of known starting point

ACS Med. Chem. Lett., May 12, 2020

Constellation Pharma., Cambridge, MA

Compound-34

“Compound 34” is a mechanism-based inhibitor of lysine-specific demethylase LSD1 (aka KDM1A). LSD1 has an FAD co-factor which is covalently modified by the cyclopropylamine in compound 34 likely through an…


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