© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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mech.-based inh. of monoamine oxidase LSD1
orally efficacious in xenograft model
from optimization of known starting point
ACS Med. Chem. Lett., May 12, 2020
Constellation Pharma., Cambridge, MA
“Compound 34” is a mechanism-based inhibitor of lysine-specific demethylase LSD1 (aka KDM1A). LSD1 has an FAD co-factor which is covalently modified by the cyclopropylamine in compound 34 likely through an…
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