selective BACE1 protease inhibitor
oral PD demonstrated on A_ in model
from optimization of prior ligand
Bioorg. Med. Chem. Lett., May 1, 2020
Amgen, Thousand Oaks, CA
“Compound 15”
“Compound 15” is a BACE1 selective inhibitor with a fluoro-olefin replacement for an N-aryl amide without the liability of a potential aniline metabolite. The compound has good oral PK in…