Chemical structure of the "Compound 15" BACE1 selective inhibitor

selective BACE1 protease inhibitor

oral PD demonstrated on A_ in model

from optimization of prior ligand

Bioorg. Med. Chem. Lett., May 1, 2020

Amgen, Thousand Oaks, CA

“Compound 15” is a BACE1 selective inhibitor with a fluoro-olefin replacement for an N-aryl amide without the liability of a potential aniline metabolite. The compound has good oral PK in…


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