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Sep. 18, 2021

BMS-986235: An FPR1-Sparing FPR2-Selective Agonist


potent, selective, oral FPR2 GPCR agonist for heart failure prevent. / entered Ph. I in HV from optimization of known ligand J. Med. Chem., May 24, 2020 Kyorin Pharmaceutical / Bristol-Myers Squibb

Drug Hunter Team

BMS-986235/LAR-1219 is an FPR1-sparing FPR2-selective agonist intended to help resolve chronic inflammation/promote wound healing to prevent serious complications like heart failure. It’s a very efficient molecule and is orally efficacious in a mouse myocardial infarction model at doses as low as 0.3 mg/pk, despite having 3 N-H donors (urea + [...]



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