fbpx

molecules of the month

BMS-986235/LAR-1219

potent, selective, oral FPR2 GPCR agonist

for heart failure prevent. / entered Ph. I in HV

from optimization of known ligand

J. Med. Chem., May 24, 2020

Kyorin Pharmaceutical / Bristol-Myers Squibb

BMS-986235-LAR-1219
1 min read

BMS-986235/LAR-1219 is an FPR1-sparing FPR2-selective agonist intended to help resolve chronic inflammation/promote wound healing to prevent serious complications like heart failure. It’s a very efficient molecule and is orally efficacious in a mouse myocardial infarction model at doses as low as 0.3 mg/pk, despite having 3 N-H donors (urea + amide) in its core. Like DS-1971a it has a PK disconnect between species (significantly lower clearance in higher species than in rodents) but was successfully taken into development. Human data hasn’t been reported yet.


request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.


already a member? log in: