PET ligand for brain O-GlcNAc hydrolase

stably visualized in human HV

discovery strategy undisclosed

Sci. Transl. Med., May 13, 2020

National Institutes of Health / Eli Lilly

structure of [18F]LSN3316612

[18F]LSN3316612 is a PET radiotracer for quantifying levels of O-GlcNAc hydrolase (OGA) in the brain. OGA is an enzyme involved in the post-translational modification of tau protein, and OGA…

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