molecules of the month


PET ligand for brain O-GlcNAc hydrolase

stably visualized in human HV

discovery strategy undisclosed

Sci. Transl. Med., May 13, 2020

National Institutes of Health / Eli Lilly

structure of [18F]LSN3316612
1 min read

[18F]LSN3316612 is a PET radiotracer for quantifying levels of O-GlcNAc hydrolase (OGA) in the brain. OGA is an enzyme involved in the post-translational modification of tau protein, and OGA may be a useful biomarker for neurodegenerative disease drug development. The fluorine radiolabel was introduced through nucleophilic aromatic substitution onto a nitropyridine.

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