oral gut-restricted Na+/H+ exchanger inhibitor
FDA-approved IBS treatment
from literature starting point and opt
ACS Med. Chem. Lett.
Ardelyx Inc., Fremont, CA/Waltham, MA
tenapanor
Context. Tenapanor (Ardelyx) is an oral, first-in-class Na+/H+ exchanger isoform 3 (NHE3) inhibitor approved by the FDA for irritable bowel syndrome with constipation (IBS-C) in adults. NHE3 is expressed…