tenapanor chemical structure, oral gut-restricted Na+/H+ exchanger inhibitor - Ardelyx Inc., Fremont, CA/Waltham, MA

oral gut-restricted Na+/H+ exchanger inhibitor

FDA-approved IBS treatment

from literature starting point and opt

ACS Med. Chem. Lett.

Ardelyx Inc., Fremont, CA/Waltham, MA

Context. Tenapanor (Ardelyx) is an oral, first-in-class Na+/H+ exchanger isoform 3 (NHE3) inhibitor approved by the FDA for irritable bowel syndrome with constipation (IBS-C) in adults. NHE3 is expressed…


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