compound 14
potent HIV-1 protease inhibitor in vitro activity (IC50 = 0.0071 μM, EC50 = 0.86 μM) from “pocket-to-lead” virtual screen and SBDD J. Med. Chem. Shionogi, Osaka, JP
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NVP-FVP954
Infection with the malaria parasite, Plasmodium falciparum, is a leading cause of fatality in the tropical regions of the world, with >240M infections and >600K deaths each year, the majority of which are in sub-Saharan Africa. The need for new antimalarials is clear, given that over half of the world's population is at risk of infection, combined with the rise of resistance against current treatments. Novartis has played a key role in this fight and at the ACS Fall 2024 meeting in Denver, CO, they disclosed NVP-FVP954: a novel, fast-acting IV antimalarial for severe malaria.
MK-5204
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