oral full agonist of GPR40 GCPR

oral efficacy in obesity model, entered Ph. I

from optimization of prior molecule

J. Med. Chem., Sep. 24, 2020

Takeda / SCOHIA Pharma, Fujisawa, JP

SCO-267 is a full agonist of the GPCR GPR40, whose activation stimulates secretions of insulin and incretin. Since no crystal structures were available, the authors used conformational modeling to rationally…


 become a member to continue reading

Ask your company or librarian about a Drug Hunter membership to to see all summaries and get access to even more helpful information.

  • Stay up-to-date and save more time with exclusive members-only content
  • On-board new team members with educational content and case studies
  • Generate ideas and discussion with easy-to-read slide decks
  • Generate ideas and discussion with easy-to-read slide decks