Structure of SCO-267, a full agonist of the GPCR GPR40

oral full agonist of GPR40 GCPR

oral efficacy in obesity model, entered Ph. I

from optimization of prior molecule

J. Med. Chem., Sep. 24, 2020

Takeda / SCOHIA Pharma, Fujisawa, JP

SCO-267 is a full agonist of the GPCR GPR40, whose activation stimulates secretions of insulin and incretin. Since no crystal structures were available, the authors used conformational modeling to rationally…

 this content is exclusive to
Premium members

Unlock this content with a Premium membership to read it now.