oral GLP-1R class B GCPR agonist

oral glucose-lowering activity observed in HV

from sensitized cell HTS of 2.8M cmpds + opt.

bioRxiv, Sep. 30, 2020

Pfizer, Cambridge, MA / Groton, CT

PF-06882961 is an oral small molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R). GLP-1R agonists increase the production of insulin and are highly useful in the treatment of diabetes. However,…


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