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Sep. 18, 2021

PF-06882961: An Oral GLP-1R Class B GPCR Agonist


oral GLP-1R class B GPCR agonist oral glucose-lowering activity observed in HV from sensitized cell HTS of 2.8M cmpds + opt. bioRxiv, Sep. 30, 2020 Pfizer, Cambridge, MA / Groton, CT

Drug Hunter Team

PF-06882961 is an oral small molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R). GLP-1R agonists increase the production of insulin and are highly useful in the treatment of diabetes. However, until the recent introduction of an oral formulation of semaglutide, GLP-1 agonists were all peptides requiring inconvenient injections. [...]



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