liver-targeted acetyl-CoA carboxylase inhibitor
oral hepatoselective activity obeserved in HV
from opt. of prior candidate for liver uptake
J. Med. Chem., Sep. 18, 2020
Pfizer, Cambridge, MA / Groton, CT
PF-05221304
PF-05221304 is a liver targeted inhibitor of acetyl-CoA carboxylase (ACC). ACC is a key regulator of lipid metabolism, and there has been significant interest in ACC inhibitors for the treatment…