Structure of OP-5244, a potent and orally active inhibitor of CD73

potent, oral CD73 nucleotidase inhibitor

oral activity in vivo, available in higher species

from SBDD of known ligand

J. Med. Chem., Sep. 24, 2020

ORIC Pharma, South San Francisco, CA

OP-5244 is a potent (250 pM), orally bioavailable inhibitor of the nucleotidase CD73, in contrast to the previously highlighted IV inhibitor in July. I thought it was remarkable that the ORIC…

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