OP-5244 is a potent (250 pM), orally bioavailable inhibitor of the nucleotidase CD73, in contrast to the previously highlighted IV inhibitor in July . I thought it was remarkable that the ORIC team was able to identify an orally available, low clearance, and permeable compound with phosphonic acid motif and four other hydrogen bond donors [...]
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Sep. 18, 2021
OP-5244: A Potent, Oral CD73 Nucleotidase Inhibitor
OP-5244
potent, oral CD73 nucleotidase inhibitor oral activity in vivo, available in higher species from SBDD of known ligand J. Med. Chem., Sep. 24, 2020 ORIC Pharma, South San Francisco, CA
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