potent, oral CD73 nucleotidase inhibitor

oral activity in vivo, available in higher species

from SBDD of known ligand

J. Med. Chem., Sep. 24, 2020

ORIC Pharma, South San Francisco, CA

OP-5244 is a potent (250 pM), orally bioavailable inhibitor of the nucleotidase CD73, in contrast to the previously highlighted IV inhibitor in July. I thought it was remarkable that the ORIC…


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