oral, CNS-penetrant, picomolar PDE1 inhibitor

Ph. I/II in neurology and heart failure

from literature starting point, LBDD and SBDD

Neuropsychopharmacology

Intra-Cellular Therapies, New York, NY

lenrispodun chemical structure, oral, CNS-penetrant, picomolar PDE1 inhibitor - Intra-Cellular Therapies, New York, NY

Context. Lenrispodun (Intra-Cellular Therapies) is a phosphodiesterase (PDE) type 1 (PDE1) inhibitor being developed for CNS and non-CNS disorders, including heart failure, and cancer. Studies to identify PDE inhibitors…


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