Context. JDQ443 (Novartis Institute for Biomedical Research) is an oral KRAS^G12C^ inhibitor being developed for various advanced solid tumors . Despite accounting for 85% of RAS oncogenic mutations in all cancers, KRAS was considered undruggable until 2013 when a report describing the targetability of the KRAS^G12C^ mutant by small molecule [...]
JDQ443: A Quickly-Advancing Oral KRAS(G12C) Inhibitor from Novartis
JDQ443
oral KRASG12C inhibitor ph. III candidate for NSCLC from de novo SBDD in SWII pocket Cancer Discov. Novartis, Basel, CH
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