oral hPTHR1 GPCR antagonist
calcium-lowering activity in rodent
scaffold-hopping from lit. starting point
Bioorg. Med. Chem.
Daiichi Sankyo, Tokyo, JP
DS69910557
Context. DS69910557 (Daiichi Sankyo) is an oral inhibitor of parathyroid hormone (PTH) type 1 receptor (PTHR1) being developed as a calcium-lowering drug. The well-characterized secretin class receptor PTH1R is…