trimethyl-lock prodrug of HCV NS5A inh.

improved bioavailability in preclinical species

from derivatization of pibrentasvir

J. Med. Chem., Sep. 3, 2020

AbbVie, North Chicago, IL

Structure of compound 9

“compound 9” is an investigational prodrug of pibrentasvir (ABT-530), a key component of AbbVie’s marketed HCV combination Mavyret. Pibrentasvir (PIB) is the largest approved oral small molecule since 1983 (MW…


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