oral WDR5 inhibitor
pM Ki, nanomolar in cells
from FBDD, SBDD, and PK opt.
J. Med. Chem.
Vanderbilt University School of Medicine, Nashville, TN
compound 41
Context. “Compound 41” (Vanderbilt University School of Medicine) is an oral WD40 Repeat Domain 5 (WDR5) inhibitor being developed for various human cancers. The well-established role of epigenetic abnormalities…