compound 41 chemical structure, oral WDR5 inhibitor - Vanderbilt University School of Medicine, Nashville, TN

oral WDR5 inhibitor

pM Ki, nanomolar in cells

from FBDD, SBDD, and PK opt.

J. Med. Chem.

Vanderbilt University School of Medicine, Nashville, TN

Context.  “Compound 41” (Vanderbilt University School of Medicine) is an oral WD40 Repeat Domain 5 (WDR5) inhibitor being developed for various human cancers. The well-established role of epigenetic abnormalities…


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