Structure of compound 23

selective degrader of IRAK3 pseudokinase

in vitro degradation in primary macrophages

from mining of internal kinase inh. and linking

J. Med. Chem., Sep. 24, 2020

AstraZeneca, Waltham, MA / Cambridge, UK

“compound 23” is a selective CRBN-based degrader of the pseudokinase, IRAK3, with in vitro activity in primary human cells. A volcano plot shows remarkable separation between IRAK3 degradation vs. most…

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