potent HIV-1 protease inhibitor

in vitro activity (IC50 = 0.0071 μM, EC50 = 0.86 μM)

from “pocket-to-lead” virtual screen and SBDD

J. Med. Chem.

Shionogi, Osaka, JP

compound 14 chemical structure, potent HIV-1 protease inhibitor - Shionogi, Osaka, JP

Context.  “Compound 14” (Shionogi) is an HIV-1 protease inhibitor being developed for HIV treatment. Despite the existence of two generations and a total of nine approved agents targeting the…


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