oral KRAS(G12C) inhibitor

oral efficacy in xenograft model

from literature starting point and SBDD

J. Med. Chem.

AstraZeneca, Cambridge, UK

AZD4625 chemical structure, oral KRAS(G12C) inhibitor - AstraZeneca, Cambridge, UK

Context. AZD4625 (AstraZeneca) is an oral inhibitor of KRASG12C being developed for the treatment of advanced solid malignancies. As indicated for JDQ443, the KRASG12C mutation presents the perfect ÔÇťAchilles…


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