oral HCV NS5B polymerase inhibitor prodrug
preclin.candidate, discont.Õd due to compet.
from optimization of prior leads
J. Med. Chem., Sep. 24, 2020
Janssen BioPharma, South San Francisco, CA
AL-611 is a prodrug to a nucleoside inhibitor of HCV NS5B polymerase. While there have been very successful nucleoside drugs (e.g. sofosbuvir), several nucleoside inhibitors of HCV previously failed in…