Structure of AL-611

oral HCV NS5B polymerase inhibitor prodrug

preclin.candidate, discont.Õd due to compet.

from optimization of prior leads

J. Med. Chem., Sep. 24, 2020

Janssen BioPharma, South San Francisco, CA

AL-611 is a prodrug to a nucleoside inhibitor of HCV NS5B polymerase. While there have been very successful nucleoside drugs (e.g. sofosbuvir), several nucleoside inhibitors of HCV previously failed in…

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