oral HCV NS5B polymerase inhibitor prodrug

preclin.candidate, discont.Õd due to compet.

from optimization of prior leads

J. Med. Chem., Sep. 24, 2020

Janssen BioPharma, South San Francisco, CA

Structure of AL-611

AL-611 is a prodrug to a nucleoside inhibitor of HCV NS5B polymerase. While there have been very successful nucleoside drugs (e.g. sofosbuvir), several nucleoside inhibitors of HCV previously failed in…

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