oral CNS-penetrant Nav1.7/1.8 blocker
in vivo efficacy in rodent pain models
electrophysiology-based HTS and opt.
Bioorg. Med. Chem.
AbbVie, North Chicago, IL
Context. ABBV-318 (AbbVie) is a CNS-penetrating, oral inhibitor of Nav1.7/Nav1.8 being developed for pain treatment. Despite being a highly validated pain target due to its important role in excitable…