4 minute read
May 13, 2022

ABBV-318: a CNS-Penetrating, Oral Inhibitor of NaV 1.7/NaV 1.8


oral CNS-penetrant Nav1.7/1.8 blocker in vivo efficacy in rodent pain models electrophysiology-based HTS and opt. Bioorg. Med. Chem. AbbVie, North Chicago, IL

Drug Hunter Team

Context. ABBV-318 (AbbVie) is a CNS-penetrating, oral inhibitor of Na v 1.7/Na v 1.8 being developed for pain treatment . Despite being a highly validated pain target due to its important role in excitable cells, Na v 1.7 inhibition has not lived up to its potential, and translation of the promising preclinical observations to human studies [...]



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