The December edition of Small Molecules of the Month includes a Ph. III candidate identified from machine-learning-assisted in vivo phenotypic screening, Mirati’s KRAS G12D inhibitor, and several kina...

The November edition of Small Molecules of the Month includes two oral SARS-CoV-2 antivirals which may play an important role in life with endemic Covid, a remarkably selective CDK7 kinase inhibitor (...

The October edition of Small Molecules of the Month includes several potential best-in-class clinical candidates including but not limited to a second-gen LPA1 antagonist from BMS, two muscle modulato...

The September edition of Small Molecules of the Month, features a number of fascinating molecules and mechanisms, including a beta-lactamase inhibitor optimized to have single agent antibiotic activit...

In August's edition of Small Molecules of the Month, we have several fascinating molecules including a tri-complex KRAS-ON inhibitor from Revolution Medicines, a targeted protein stabilizer from a Ber...

July’s edition of Small Molecules of the Month, features a selective monovalent estrogen receptor degrader in Ph. III, a remarkable 4(!) neurology clinical candidates from Takeda (including 2 recently...

June’s edition of Small Molecules of the Month features a natural product-derived RNA splicing modulator, a mTORC1-selective “bi-steric” inhibitor, numerous low-dose clinical candidates and several un...

In May’s edition of Small Molecules of the Month, we have several fascinating molecules including a mutant PI3Kα degrader in Ph. III (GDC-0077, inavolisib), a wild-type CFTR potentiator for COPD, and...

In April’s edition of Small Molecules of the Month, we have several fascinating molecules including a tri-complex KRAS-ON inhibitor from Revolution Medicines, a targeted protein stabilizer from a Berk...

The March 2021 edition of Drug Hunter‘s Small Molecules of the Month series contains several small molecule clinical candidates as well as pre-clinical small molecules with interesting structures or m...

February was a packed month for interesting molecules – there were nearly 20 molecules we thought about including in this list but couldn’t fit them all. There are several clinical candidates this mon...

For the first installment of Drug Hunter’s “Small Molecules of the Month” series in 2021, we have a Kissei SGLT2 inhibitor whose lead was a metabolite found in mouse urine, a GSK integrin inhibitor th...

In 2021 Drug Hunter highlighted 168 Molecules of the Month whose structures or stories were published for the first time, or had significant disclosures of new data. Here are the top 12 Molecules of t...